Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance.
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چکیده
منابع مشابه
Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance.
Two studies are reported; a double-blind cross-over trial of feprazone 600 mg daily and aspirin 3.6 g daily in the treatment of rheumatoid arthritis, and an uncontrolled open study of gastrointestinal tolerance in twenty rheumatoid arthritis patients with known intolerance to other drugs. The first study showed that feprazone was significantly superior to aspirin in all the parameters tested. I...
متن کامل[Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumoristatic agent].
OBJECTIVE To explore the potential anti-inflammatory and analgesic activities of carboxyamidotriazole (CAI). METHODS A variety of animal models, including the croton oil-induced ear edema, the cotton-induced granuloma, the rat adjuvant-induced arthritis, were used to evaluate anti-inflammatory effect of CAI. Vascular endothelial growth factor (VEGF)--or histamine-stimulated local vascular per...
متن کاملAnti-Inflammatory and Analgesic Potency of Carboxyamidotriazole, a Tumorostatic Agent
Carboxyamidotriazole (CAI) is a calcium influx inhibitor that is undergoing clinical trials for the treatment of various human cancers following the identification of its antiproliferative and antimetastatic activities. The exact mechanism of its action is not clearly understood, and whether it has other functions besides the established antitumor activity has not been reported either. In the p...
متن کاملToward a new anti-inflammatory and analgesic agent.
I a comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al. (1) provide evidence in this issue of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception. B1 receptors are generally silent or absent in healthy states and are induced or activated by pathological challenges. When they are absent, as in B1-KO mice, ti...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1975
ISSN: 0003-4967
DOI: 10.1136/ard.34.2.190